National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/14720

Target Organs and Levels of Evidence for TR-033

Bioassay of Tetrachlorvinphos for Possible Carcinogenicity (CASRN 961-11-5)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Tetrachlorvinphos
961-11-5
11/28/1977Pesticide, cholinesterase inhibitor (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R: 0,4250,8500 (AVG), M: 0,800,1600 PPM/50 PER GROUP
Gulf South Research Institute

Levels of Evidence

Male Rats: Negative
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland C-Cell: ADENOMA
  • Adrenal Gland Cortex: ADENOMA
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (NEOPLASTIC NODULE)


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