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Target Organs and Levels of Evidence for TR-034

Bioassay of Trifluralin for Possible Carcinogenicity (CASRN 1582-09-8)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Trifluralin
1582-09-8
01/18/1977Pre-emergence herbicide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
MR: 0,4125,8000 (AVG), FR: 0,4125,7917 (AVG), MM: 0,2000,3744 (AVG), FM: 02740,5192 (AVG) PPM/50 PER GROUP
Hazleton, Vienna

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Negative
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
  • Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA)
  • Forestomach: (SQUAMOUS CELL CARCINOMA)