National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/14732

Target Organs and Levels of Evidence for TR-039

Bioassay of Lasiocarpine for Possible Carcinogenicity (CASRN 303-34-4)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Lasiocarpine
303-34-4
11/28/1978Carcinogen in research, use in India to treat snakebites, as an emetic, hepatotoxic pyrrolizidine (Merck 1989)Dosed-Feed
0, 7, 15, or 30 ppm/48 per group
SRI International

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: Angiosarcoma, carcinoma, adenoma
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: Angiosarcoma, carcinoma, adenoma
  • Hematopoietic System: Lymphoma/Leukemia


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