National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/14750

Target Organs and Levels of Evidence for TR-049

Bioassay of Acronycine for Possible Carcinogenicity (CASRN 7008-42-6)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Acronycine
7008-42-6
03/07/1978Anticancer drugIntraperitoneal Injection
R: 0,3.75,7.5,15, M: 0,2,6,12.5,25 MG/KG/35 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Bone: (OSTEOSARCOMA)
  • Mesothelium (Abdominal Cavity/Tunica Vaginalis): MESOTHELIOMA; SARCOMA
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Mammary Gland: (ADENOCARCINOMA)
  • Mesothelium (Abdominal Cavity/Tunica Vaginalis): MESOTHELIOMA; SARCOMA
Male Mice: Inadequate Study
Female Mice: Inadequate Study


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