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Target Organs and Levels of Evidence for TR-058

Bioassay of Thio-TEPA for Possible Carcinogenicity (CASRN 52-24-4)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
tris(Aziridinyl)-phosphine sulfide (thio-tepa)
52-24-4
04/26/1978Treatment of megaloblastic anemia. Poultry feed supplement. In foods & beverages.Intraperitoneal Injection
R: 0,.7,1.4,2.8, M: 0,1.15,2.3 MG/KG/35 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: (LYMPHOMA OR LEUKEMIA)
  • Zymbal Gland: (SQUAMOUS CELL CARCINOMA)
  • Skin: (SQUAMOUS CELL CARCINOMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Zymbal Gland: (SQUAMOUS CELL CARCINOMA)
  • Skin: (SQUAMOUS CELL CARCINOMA)
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: (LYMPHOMA, LEUKEMIA)
  • Skin: (SQUAMOUS CELL CARCINOMA)
  • Preputial Gland: (SQUAMOUS CELL CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: (LYMPHOMA, LEUKEMIA)