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Target Organs and Levels of Evidence for TR-059

Bioassay of Estradiol Mustard for Possible Carcinogenicity (CASRN 22966-79-6)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Estradiol mustard
22966-79-6
04/26/1978Anticancer drugGavage
R: 0,.62,1.25, M: 0,15,30 MG/KG/35 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR CARCINOMA)
  • Hematopoietic System: (LYMPHOMA OR LEUKEMIA)
  • Heart: (SARCOMA)
  • Forestomach: (SQUAMOUS CELL CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA)
  • Hematopoietic System: (LYMPHOMA)
  • Heart: (SARCOMA)
  • Forestomach: (SQUAMOUS CELL CARCINOMA)