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Target Organs and Levels of Evidence for TR-076

Bioassay of Tris (2,3-Dibromopropyl) Phosphate for Possible Carcinogenicity (CASRN 126-72-7)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
tris(2,3-Dibromopropyl) phosphate
126-72-7
03/06/1978Flame retardantDosed-Feed
R: 0,50,100, M: 0,500,1000 PPM/55 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA, ADENOMA OR ADENOCARCINOMA
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA OR ADENOCARCINOMA
  • Forestomach: (SQUAMOUS CELL PAPILLOMA, SQUAMOUS CELL PAPILLOMA OR CARCINOMA)
  • Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: (SQUAMOUS CELL PAPILLOMA, SQUAMOUS CELL CARCINOMA)
  • Liver: (ADENOMA, CARCINOMA)
  • Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA)