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Target Organs and Levels of Evidence for TR-081

Bioassay of Trimethylphosphate for Possible Carcinogenicity (CASRN 512-56-1)

Chemical (Study Title)
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
03/06/1978Gasoline additive for controlling surface ignition and spark plug fouling; methylating agent, chemical intermediate in the production of polymethyl polyphosphates; flame retardant solvent for paints and polymers; catalyst in the preparation of polymers and resins. Stabilizer; antioxidantGavage
R: 0,50,100, M: 0,250,500 MG/KG/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Subcutaneous Tissue: (FIBROMA)
Female Rats: Negative
Male Mice: Negative
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Uterus/Cervix: (ADENOCARCINOMA)