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https://ntp.niehs.nih.gov/go/8248

Target Organs and Levels of Evidence for TR-084

Bioassay of 2,4-Diaminoanisole Sulfate for Possible Carcinogenicity (CASRN 615-05-4)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
2,4-Diaminoanisole sulfate
39156-41-7
03/06/1978Shoe polishes; (formerly) hair dyesDosed-Feed
R: 0,.12,.5 (AVG), M: 0,.12,.24 %/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland C-Cell: ADENOMA OR CARCINOMA
  • Thyroid Gland Follicular Cell: ADENOMA OR CARCINOMA
  • Skin: (SQUAMOUS CELL CARCINOMA OR BASAL CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA)
  • Zymbal Gland: (SQUAMOUS CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA)
  • Preputial Gland: (ADENOMA OR CARCINOMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA OR CARCINOMA
  • Zymbal Gland: (SEBACEOUS ADENOCARCINOMA)
  • Clitoral Gland: (ADENOMA OR CARCINOMA)
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA OR CARCINOMA