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Target Organs and Levels of Evidence for TR-085

Bioassay of 4-Chloro-m-phenylenediamine for Possible Carcinogenicity (CASRN 5131-60-2)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
4-Chloro-m-phenylenediamine
5131-60-2
04/26/1978Used as a chemical intermediate for dyestuffs and pigments, a hair dye coupler, a rubber-processing agent, and a research chemical.Dosed-Feed
R: 0,.2,.4, M: 0,.7,1.4 (AVG) %DIET/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA
Female Rats: Negative
Male Mice: Negative
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (ADENOMA OR CARCINOMA)