https://ntp.niehs.nih.gov/go/9591

4-Chloro-m-phenylenediamine: Target Organs and Levels of Evidence for TR-085

Bioassay of 4-Chloro-m-phenylenediamine for Possible Carcinogenicity (CASRN 5131-60-2)

Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
4-Chloro-m-phenylenediamine
5131-60-2
04/26/1978 Dosed-Feed
R: 0,.2,.4, M: 0,.7,1.4 (AVG) %DIET/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA
Female Rats: Negative
Male Mice: Negative
Female Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (ADENOMA OR CARCINOMA)