National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9593

Target Organs and Levels of Evidence for TR-086

Bioassay of 1,2-Dibromoethane for Possible Carcinogenicity (CASRN 106-93-4)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1,2-Dibromoethane
106-93-4
04/26/1978Scavenger for lead in gasoline; soil and grain fumigant; intermediate for dyes and drugs. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
MR: 0,38,41 (AVG), FR: 0,37,39 (AVG), M: 0,62,107 MG/KG/50 PER GROUP
Hazleton, Vienna

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL CARCINOMA
  • Vascular System (Unspecified): HEMANGIOSARCOMA
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: (SQUAMOUS CELL CARCINOMA)
  • Liver: (CARCINOMA)
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: (SQUAMOUS CELL CARCINOMA)
  • Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: (SQUAMOUS CELL CARCINOMA)
  • Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA)


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