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Target Organs and Levels of Evidence for TR-088

Bioassay of 1H-Benzotriazole for Possible Carcinogenicity (CASRN 95-14-7)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1,2,3-Benzotriazole
95-14-7
04/26/1978Photographic restrainer; chemical intermediate; copper corrosion inhibitor; intermediate for dyes, pharmaceuticals, in de-icing fluids for aircraft (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R: 0,6700,12100 M:0,11700,23500 PPM/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Brain: (GLIOMA OR OLIGODENDROGLIOMA)
Female Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Brain: (GLIOMA)
Male Mice: Negative
Female Mice: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: (ALVEOLAR/BRONCHIOLAR CARCINOMA)