National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9597

Target Organs and Levels of Evidence for TR-089

Bioassay of o-Anisidine Hydrochloride for Possible Carcinogenicity (CASRN 134-29-2)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
o-Anisidine hydrochloride
134-29-2
04/26/1978Manufacture of azo dyes; formerly listed as possible ingredient in permanent oxidation hair dyes (no longer used in the US). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R: 0,5000,10000, M: 0,2500,5000 PPM/55 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Urinary Bladder: (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)
  • Kidney Transitional Cell: CARCINOMA
  • Thyroid Gland Follicular Cell: ADENOMA OR CARCINOMA
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Urinary Bladder: (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Urinary Bladder: (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Urinary Bladder: (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)


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