National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9603

Target Organs and Levels of Evidence for TR-092

Bioassay of Hydrazobenzene for Possible Carcinogenicity (CASRN 122-66-7)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Hydrazobenzene
122-66-7
04/26/1978Precursor for dyes; preparation of phenylbutazone. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
MR: 0,.008,.03 (AVG), FR: 0,.004,.01 (AVG), MM: 0,.008,.04 (AVG), FM: 0,.004,.04 (AVG) %/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
  • Zymbal Gland: (SQUAMOUS CELL PAPILLOMA OR CARCINOMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (NEOPLASTIC NODULE)
  • Mammary Gland: (ADENOCARCINOMA)
Male Mice: Negative
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)


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