National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9609

Target Organs and Levels of Evidence for TR-095

Bioassay of 3-(Chloromethyl)pyridine Hydrochloride for Possible Carcinogenicity (CASRN 6959-48-4)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
3-Chloromethylpyridine hydrochloride
6959-48-4
10/25/1978Research chemical. An intermediate that has been proposed for use in the synthesis of agricultural, pharmaceutical, and veterinary chemicals.Gavage
R: 0,75,150, M: 0,100,200 MG/KG/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: (SQUAMOUS CELL PAPILLOMA OR CARCINOMA)
Female Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: (SQUAMOUS CELL CARCINOMA)
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: (SQUAMOUS CELL PAPILLOMA OR CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: (SQUAMOUS CELL PAPILLOMA OR CARCINOMA)


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