National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9617

Target Organs and Levels of Evidence for TR-099

Bioassay of Phenazopyridine Hydrochloride for Possible Carcinogenicity (CASRN 136-40-3)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Phenazopyridine hydrochloride
136-40-3
04/26/1978Urinary analgesic (Merck 1989); azo dye.Dosed-Feed
R: 0,3700,7500, M: 0,600,1200 PPM/35 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Intestines: (ADENOCARCINOMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Intestines: (ADENOCARCINOMA)
Male Mice: Negative
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (ADENOMA, CARCINOMA)


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