National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/10947

Target Organs and Levels of Evidence for TR-107

Bioassay of 5-Nitro-o-toluidine for Possible Carcinogenicity (CASRN 99-55-8)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
5-Nitro-o-toluidine
99-55-8
04/26/1978Dye intermediateDosed-Feed
R: 0,.005,.01, M: 0,.12,.23 %/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA
  • Vascular System (Unspecified): HEMANGIOMA OR HEMANGIOSARCOMA
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA
  • Vascular System (Unspecified): HEMANGIOSARCOMA


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