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Target Organs and Levels of Evidence for TR-108

13-Week Subchronic Toxicity Studies of Direct Blue 6, Direct Black 38, and Direct Brown 95 Dyes

Chemical (Study Title)
CASRN
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
C.I. Direct black 38
1937-37-7
03/06/1978 Dye for textiles, leather, ink; biological and wood stains; hair dyes (formerly used) Dosed-Feed
R: 0,190,375,750,1500,3000, M: 0,750,1500,3000,6000,12500 PPM/10 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: Carcinoma, neoplastic nodules
Female Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: Carcinoma, neoplastic nodules


Chemical (Study Title)
CASRN
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
C.I. Direct blue 6
2602-46-2
03/06/1978 Dye for textiles, leather, ink; biological and wood stains; hair dyes (formerly used) Dosed-Feed
R: 0, 750, 1500, 2000, 6000, OR 12500 PPM M: 0, 190, 375, 750, 1500, OR 3000 PPM
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: Carcinoma, neoplastic nodules
Female Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: Carcinoma, neoplastic nodules


Chemical (Study Title)
CASRN
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
C.I. Direct brown 95
16071-86-6
03/06/1978 Dye for textiles, leather, plastics, paper Dosed-Feed
R: 0,190,375,750,1500,3000, MM: 0,750,1500,3000,6000,12500, FM: 0,375,750,1500,3000,6000 PPM/10 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Negative
Female Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: Carcinoma, neoplastic nodules