National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13415

Target Organs and Levels of Evidence for TR-118

Bioassay of 5-Nitroacenaphthene for Possible Carcinogenicity (CASRN 602-87-9)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
5-Nitroacenaphthene
602-87-9
06/29/1978Research chemical; in Japan as intermediate for dyes in detergentsDosed-Feed
R: 0,.12,.24, MM: 0,.06,.12 (AVG), FM: 0,.05,.12 (AVG) %/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Zymbal Gland: (CARCINOMA)
  • Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Zymbal Gland: (CARCINOMA)
  • Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA)
  • Mammary Gland: (ADENOCARCINOMA)
  • Clitoral Gland: (CARCINOMA)
Male Mice: Negative
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
  • Ovary: (TUBULAR CELL ADENOMA OR GRANULOSA CELL TUMOR OR LUTEOMA)


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