National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13433

Target Organs and Levels of Evidence for TR-128

Bioassay of 3,3'-Dimethoxybenzidine-4,4'-diisocyanate for Possible Carcinogenicity (CASRN 91-93-0)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
3,3'-Dimethoxybenzidine-4,4'-diisocyanate
91-93-0
08/31/1978Polyurethane elastomers; adhesivesDosed-Feed
0,22000,44000 PPM/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Skin: (BASAL CELL ADENOMA, SQUAMOUS CELL CARCINOMA)
  • Hematopoietic System: (LYMPHOMA OR LEUKEMIA)
  • Zymbal Gland: (CARCINOMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: (LYMPHOMA OR LEUKEMIA)
  • Uterus/Cervix: (POLYP)
  • Zymbal Gland: (CARCINOMA)
Male Mice: Negative
Female Mice: Negative


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