National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13437

Target Organs and Levels of Evidence for TR-130

Bioassay of Aniline Hydrochloride for Possible Carcinogenicity (CASRN 142-04-1)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Aniline hydrochloride
142-04-1
06/29/1978Chemical intermediate; printing and dyeing of fabric and wood, aniline base occurs in coal tar (Merck 1989)Dosed-Feed
R: 0,.3,.6, M: 0,.6,1.2 %/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Spleen): HEMANGIOSARCOMA; SARCOMA OR FIBROSARCOMA
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Spleen: SARCOMA
Male Mice: Negative
Female Mice: Negative


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