Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/13437

Target Organs and Levels of Evidence for TR-130

Bioassay of Aniline Hydrochloride for Possible Carcinogenicity (CASRN 142-04-1)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Aniline hydrochloride
142-04-1
06/29/1978Chemical intermediate; printing and dyeing of fabric and wood, aniline base occurs in coal tar (Merck 1989)Dosed-Feed
R: 0,.3,.6, M: 0,.6,1.2 %/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Spleen): HEMANGIOSARCOMA; SARCOMA OR FIBROSARCOMA
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Spleen: SARCOMA
Male Mice: Negative
Female Mice: Negative