National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13439

Target Organs and Levels of Evidence for TR-131

Bioassays of DDT, TDE, and p,p'-DDE for Possible Carcinogenicity (CASRN 50-29-3, CASRN 72-54-8, CASRN 72-55-9)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
p,p'-Dichlorodiphenyl dichloroethylene
72-55-9
06/24/1978Insecticide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
MR: 0,437,839 (AVG), FR: 0,242,462 (AVG), M: 0,148,261 (AVG) PPM/50 PER GROUP
Hazleton, Vienna

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)


Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Dichlorodiphenyltrichloroethane (DDT)
50-29-3
06/29/1978Insecticide. Pediculicide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
MR: 0,321,642 (AVG), FR: 0,210,420 (AVG), MM: 0,22,44 (AVG), FM: 0,87,175 (AVG) PPM/50 PER GROUP
Hazleton, Vienna

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Negative
Female Mice: Negative


Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Tetrachlorodiphenylethane
72-54-8
06/29/1978Insecticide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
FR: 0,850,1700 (AVG), MR: 0,1647,3294 (AVG), M: 0,411,822 (AVG) PPM/50 PER GROUP
Hazleton, Vienna

Levels of Evidence

Male Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA OR CARCINOMA
Female Rats: Negative
Male Mice: Negative
Female Mice: Negative


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