National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/7114

Target Organs and Levels of Evidence for TR-140

Bioassay of Pivalolactone for Possible Carcinogenicity (CASRN 1955-45-9)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Pivalolactone
1955-45-9
06/29/1978Intermediate for polymersGavage
R: 0,150,300, M: 0,75,150 MG/KG/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: (SQUAMOUS CELL PAPILLOMA OR CARCINOMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: (SQUAMOUS CELL PAPILLOMA OR CARCINOMA)
Male Mice: Negative
Female Mice: Negative


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