National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/6201

Target Organs and Levels of Evidence for TR-154

Bioassay of Azobenzene for Possible Carcinogenicity (CASRN 103-33-3)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Azobenzene
103-33-3
12/13/1978Intermediate for azo dyes and other organic chemicals, acaricide (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R&MM: 0,200,400, FM: 0,208,545 (AVG) PPM/50 PER GROUP
Frederick Cancer Research Facility

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Spleen: (SARCOMA, FIBROSARCOMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Spleen: (FIBROSARCOMA)
Male Mice: Negative
Female Mice: Negative


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