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https://ntp.niehs.nih.gov/go/6213

Target Organs and Levels of Evidence for TR-160

Bioassay of 2,4,5-Trimethylaniline for Possible Carcinogenicity (CASRN 137-17-7)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
2,4,5-Trimethylaniline
137-17-7
12/13/1978Synthesis of the dye Ponceau 3R.Dosed-Feed
R: 0,200,800, M: 0,50,100 PPM/50 PER GROUP
Frederick Cancer Research Facility

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (NEOPLASTIC NODULE, CARCINOMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (NEOPLASTIC NODULE, CARCINOMA)
  • Lung: (ALVEOLAR/BRONCHIOLAR CARCINOMA)
Male Mice: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)