National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8413

Target Organs and Levels of Evidence for TR-185

Bioassay of Styrene for Possible Carcinogenicity (CASRN100-42-5)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Styrene
100-42-5
10/25/1978In manufacture of plastics, synthetic rubber, resins. Insulator. Used in construction materials and boats. Chemical intermediate. Flavoring agent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R: 0,500,1000,2000, M: 0,150,300 MG/KG/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA)
Female Mice: Negative


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