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Target Organs and Levels of Evidence for TR-189

Bioassay of p-Chloroaniline for Possible Carcinogenicity (CASRN 106-47-8)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
p-Chloroaniline
106-47-8
10/25/1978Dyes; intermediate for pharmaceuticals and agricultural chemicals. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R: 0,250,500, M: 0,2500,5000 PPM/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Spleen: SARCOMA
Female Rats: Negative
Male Mice: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Unspecified): HEMANGIOSARCOMA
Female Mice: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Unspecified): HEMANGIOSARCOMA