National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8421

Target Organs and Levels of Evidence for TR-190

Bioassay of p-Nitrosodiphenylamine for Possible Carcinogenicity (CASRN 156-10-5)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
p-Nitrosodiphenylamine
156-10-5
10/25/1978Accelerator in rubber vulcanization, intermediate. For dyes & drugs, inhibitor of styrene-type polymerization (HSDB)Dosed-Feed
R: 0,2500,5000, M: 0,4254,9000 (AVG) PPM/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (NEOPLASTIC NODULE OR CARCINOMA)
Female Rats: Negative
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
Female Mice: Negative


NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.