National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9774

Target Organs and Levels of Evidence for TR-206

Carcinogenesis Bioassay of 1,2-Dibromo-3-chloropropane (CASRN 96-12-8) in F344 Rats and B6C3F1 Mice (Inhalation Study)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1,2-Dibromo-3-chloropropane
96-12-8
06/27/1980Soil fumigant. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
0,0.6,3.0 PPM/50 PER GROUP
Hazleton, Vienna

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: BENIGN AND MALIGNANT TUMORS 0/50 32/50 39/49
  • Oral Cavity: SQUAMOUS CELL PAPILLOMA 0/50 1/50 8/49; SQUAMOUS CELL CARCINOMA 0/50 0/50 3/49
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: BENIGN AND MALIGNANT TUMORS 1/50 21/50 32/50
  • Oral Cavity: SQUAMOUS CELL PAPILLOMA 0/50 3/50 11/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 5/50
  • Adrenal Gland Cortex: ADENOMA 0/50 7/50 5/48
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: BENIGN AND MALIGNANT TUMORS 0/45 1/42 21/48
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/41 1/40 6/45; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/41 2/40 1/45
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: BENIGN AND MALIGNANT TUMORS 0/50 11/50 38/50
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 3/49 10/47; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/49 2/49 4/47


NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.