National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9782

Target Organs and Levels of Evidence for TR-210

Carcinogenesis Bioassay of 1,2-Dibromoethane (CASRN 106-93-4) in F344 Rats and B6C3F1 Mice (Inhalation Study)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1,2-Dibromoethane
106-93-4
06/27/1980Scavenger for lead in gasoline; soil and grain fumigant; intermediate for dyes and drugs. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
0,10,40 PPM/50 PER GROUP
Hazleton, Vienna

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOMA 0/50 11/50 0/50; ADENOCARCINOMA 0/50 20/50 28/50; CARCINOMA 0/50 0/50 21/50
  • Vascular System (Unspecified): HEMANGIOSARCOMA 0/50 1/50 15/50
  • Mesothelium (Abdominal Cavity/Tunica Vaginalis): MESOTHELIOMA 0/50 7/50 25/50
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOMA 0/50 11/50 3/50; ADENOCARCINOMA 0/50 20/50 29/50; CARCINOMA 0/50 0/50 25/50
  • Vascular System (Unspecified): HEMANGIOSARCOMA 0/50 0/50 5/50
  • Mammary Gland: FIBROADENOMA 4/50 29/50 24/50
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 0/48 1/47 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/48 4/47 COMBINED 0/50 0/48 5/47
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/41 0/48 11/46; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/41 3/48 19/46
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 7/49 13/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/49 5/49 37/50
  • Vascular System (Unspecified): HEMANGIOSARCOMA 0/50 11/50 23/50
  • Subcutaneous Tissue: FIBROSARCOMA 0/50 5/50 11/50
  • Nasal Cavity: CARCINOMA 0/50 0/50 6/50
  • Mammary Gland: ADENOCARCINOMA 2/50 14/50 8/50


NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.