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Target Organs and Levels of Evidence for TR-212

Carcinogenesis Bioassay of Di(2-ethylhexyl)adipate (CASRN 103-23-1) in F344 Rats and B6C3F1 Mice (Feed Study)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Di(2-ethylhexyl)adipate
103-23-1
06/27/1980Plasticizer added to polyvinyl plastics and vacuum pump fluid. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
0,12000,25000 PPM/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 6/50 8/49 15/49
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 1/50 14/50 12/49