National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9788

Target Organs and Levels of Evidence for TR-213

Carcinogenesis Bioassay of Butyl Benzyl Phthalate (CASRN 85-68-7) in F344/N Rats and B6C3F1 Mice (Feed Study)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Butyl benzyl phthalate
85-68-7
06/23/1981Plasticizer for PVC-based flooring products. Also used in biodegradable tampon ejectors, organic intermediate. A plasticizer for vinyl chloride plastics. A plasticizer added to polymers to give flexibility and softness. It is used extensively in polyvinyl chloride and in cellulose plastics, polyvinyl acetate, polysulfides, and polyurethane.Dosed-Feed
0,6000,12000 PPM/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Inadequate Study
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: LEUKEMIA 7/49 7/49 18/50
Male Mice: Negative
Female Mice: Negative


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