National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9796

Target Organs and Levels of Evidence for TR-217

Carcinogenesis Bioassay of Di(2-ethylhexyl)phthalate (CASRN 117-81-7) in F344 Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Di(2-ethylhexyl) phthalate
117-81-7
10/15/1980Plasticizer added to vacuum pump fluid, PVC polymers, elastomers, rubber & resins, agaricide used in orchards, inert ingredient in pesticide formulations, in dielectric fluids, photographic film, adhesives, cosmetics, detergents (HSDB 1990). The most commonly used plasticizer for polyvinylchloride polymers. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R: 0,6000,12000, M: 0,3000,6000 PPM/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: NEOPLASTIC NODULE 2/50 5/49 7/49 OR CARCINOMA 1/50 1/49 5/49 COMBINED 3/50 6/49 12/49
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 0/50 2/49 8/50
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 9/50 14/48 19/50
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 0/50 7/50 17/50


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