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Target Organs and Levels of Evidence for TR-222

Carcinogenesis Bioassay of Disperse Yellow 3 (CASRN 2832-40-8) in F344 Rats and B6C3F1 Mice (Feed Study)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
C.I. Disperse yellow 3
2832-40-8
02/18/1981Monoazo dye in nylon, wool, fur, polyvinyl chloride, acrylic fibers, polystyrene, other thermoplasticsDosed-Feed
R: 0,5000,10000, M: 0,2500,5000 PPM/50 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: NEOPLASTIC NODULE 1/49 15/50 10/50
May Have Been Related
  • Glandular Stomach: ADENOMA 0/49 1/50 0/50; ADENOCARCINOMA 0/49 1/501/50; SARCOMA 0/49 0/50 1/50
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/49 1/50 0/50; FIBROSARCOMA 0/49 1/50 0/50; SARCOMA 0/49 0/50 1/50
Female Rats: Negative
Male Mice: Negative
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 0/50 6/50 12/50
May Have Been Related
  • Hematopoietic System: LYMPHOMA 10/50 16/50 19/50