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Target Organs and Levels of Evidence for TR-232

Carcinogenesis Studies of Pentachloroethane (CASRN 76-01-7) in F344/N Rats and B6C3F1 Mice (Gavage Study)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Pentachloroethane
76-01-7
06/23/1981Solvent, cleansing and degreasing metalsGavage
R: 0,75,150, M: 0,250,500 MG/KG/50 PER GROUP
Gulf South Research Institute

Levels of Evidence

Male Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 1/49 4/50; ADENOMA OR ADENOCARCINOMA COMBINED 1/50 2/49 4/50
Non-Neoplastic Lesions
  • KIDNEY: INFLAMMATION, CHRONIC, DIFFUSE; PAPILLA, MINERALIZATION
Female Rats: Negative
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 4/48 26/44 7/45
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 2/46 8/42 19/45; CARCINOMA 1/46 28/42 13/45