National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/7148

Target Organs and Levels of Evidence for TR-236

Carcinogenesis Bioassay of D-Mannitol (CASRN 69-65-8) in F344/N Rats and B6C3F1 Mice (Feed Study)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
D-Mannitol
69-65-8
12/16/1981Chewable tablets, sugar replacement, candies and gums, osmotic diuretic, and fluid replacement. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
0,25000,50000 PPM/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Negative
Female Mice: Negative


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