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Target Organs and Levels of Evidence for TR-238

Carcinogenesis Bioassay of Ziram (CASRN 137-30-4) in F344/N Rats and B6C3F1 Mice (Feed Study)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Ziram
137-30-4
12/16/1981Fungicide & accelerator in rubber vulcanization.Dosed-Feed
R: 0, 300, OR 600 PPM M: 0, 600, OR 1200 PPM
Southern Research Institute

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland C-Cell: CARCINOMA 0/50 2/49 7/49
Female Rats: Negative
Male Mice: Negative
Female Mice: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 5/49 10/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 1/49 1/50 COMBINED 4/50 6/49 11/50