National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/7170

Target Organs and Levels of Evidence for TR-248

Carcinogenesis Studies of 4,4'-Methylenedianiline Dihydrochloride (CASRN 13552-44-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
4,4'-Methylenedianiline dihydrochloride
13552-44-8
06/16/1982Intermediate for isocyanates and polyisocyanatesDosed-Water
0,150,300 PPM/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: CARCINOMA 0/49 0/47 7/48
  • Liver: NEOPLASTIC NODULE 1/50 12/50 25/50
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 0/47 2/47 17/48
  • Thyroid Gland C-Cell: ADENOMA 0/47 3/47 6/48
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 0/47 3/49 16/49
  • Liver: CARCINOMA 10/49 33/50 29/50
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 2/48 12/49 14/49
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 0/50 1/47 13/50
  • Liver: ADENOMA 3/50 9/50 12/50
  • Hematopoietic System: LYMPHOMA 13/50 28/50 29/50


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