National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/7176

Target Organs and Levels of Evidence for TR-251

Toxicology and Carcinogenesis Studies of Commercial Grade 2,4 (80)- and 2,6 (20)- Toluene Diisocyanate (CASRN 26471-62-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
2,4- & 2,6-Toluene diisocyanate
26471-62-5
09/22/1982Manufacture of flexible polyurethane foams and coatings for lacquer and wood finishesGavage
MR: 0,30,60, FR&FM: 0,60,120, MM: 0,120,240, MG/KG/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Subcutaneous Tissue: FIBROMA 3/50 3/50 9/50 OR FIBROSARCOMA 0/50 3/50 3/50 COMBINED 3/50 6/50 12/50
  • Pancreas Acinar Cell: ADENOMA 1/47 3/47 7/49
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Subcutaneous Tissue: FIBROMA 0/50 1/50 3/50 OR FIBROSARCOMA 2/50 0/50 2/50 COMBINED 2/50 1/50 5/50
  • Liver: NEOPLASTIC NODULE 3/50 8/50 8/48
  • Pancreas Islet Cell: ADENOMA 0/50 6/49 2/47 CARCINOMA 0/50 1/49 0/47 COMBINED 0/50 7/49 2/47
  • Mammary Gland: FIBROADENOMA 15/50 21/50 18/50
Male Mice: Negative
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Unspecified): HEMANGIOMA 0/50 1/50 2/50 OR HEMANGIOSARCOMA 0/50 0/50 3/50 COMBINED 0/50 1/50 5/50
  • Liver: ADENOMA 2/50 3/50 12/50


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