National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/7590

Target Organs and Levels of Evidence for TR-253

Carcinogenesis Studies of Allyl Isovalerate (CASRN 2835-39-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Allyl isovalerate
2835-39-4
09/22/1982Fragrance in cosmetics, flavoring agent in foodsGavage
0,31,62 MG/KG/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: LEUKEMIA 1/50 4/50 7/50
Female Rats: Negative
Male Mice: Negative
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: LYMPHOMA 11/50 11/50 18/50


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