National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/10779

Target Organs and Levels of Evidence for TR-269

Toxicology and Carcinogenesis Studies of TeloneĀ® (Technical-Grade 1,3-Dichloropropane [CASRN 542-75-6] Containing 1.0 Epichlorohydrin as a Stabilizer) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1,3-Dichloropropene (Telone II)
542-75-6
07/27/1984Soil fumigant, nematocide (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R: 0,25,50, M: 0,50,100 MG/KG/50 PER GROUP
Frederick Cancer Research Facility

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 1/52 1/52 9/52; SQUAMOUS CELL CARCINOMA 0/52 0/52 4/52
  • Liver: NEOPLASTIC NODULE 1/52 6/52 7/52
Non-Neoplastic Lesions
  • FORESTOMACH: HYPERPLASIA, EPITHELIAL; HYPERPLASIA, BASAL CELL
Female Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/52 2/52 3/52
Non-Neoplastic Lesions
  • FORESTOMACH: HYPERPLASIA, EPITHELIAL; HYPERPLASIA, BASAL CELL
Male Mice: Inadequate Study
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: HYPERPLASIA, EPITHELIAL
  • URINARY BLADDER: HYPERPLASIA, EPITHELIAL
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Urinary Bladder: TRANSITIONAL CELL CARCINOMA 0/50 8/50 21/48
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 3/50 8/50
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 1/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 0/50 1/50 4/50
Non-Neoplastic Lesions
  • FORESTOMACH: HYPERPLASIA, EPITHELIAL
  • URINARY BLADDER: HYPERPLASIA, EPITHELIAL


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