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Target Organs and Levels of Evidence for TR-271

Toxicology and Carcinogenesis Studies of HC Blue No. 1 (CASRN 2784-94-3) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
HC blue 1
2784-94-3
03/23/1984Formerly used as a component of non-oxidation hair dyes.Dosed-Feed
R&MM: 0,1500,3000, FM: 0,3000,6000 PPM/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: NEOPLASTIC NODULE 0/49 0/50 3/50; CARCINOMA 1/49 0/50 6/50
Female Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 2/49 3/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/49 4/50 COMBINED 1/50 3/49 7/50
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 11/50 20/50 30/50
May Have Been Related
  • Thyroid Gland Follicular Cell: ADENOMA 0/47 0/49 5/50
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 1/50 24/48 47/49