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Target Organs and Levels of Evidence for TR-273

Toxicology and Carcinogenesis Studies of Trichloroethylene (CASRN 79-01-6) in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Trichloroethylene
79-01-6
08/19/1986 Degreaser, dry cleaning solvent, manufacture or organic chemicals and pharmaceuticals, heat exchange liquid, diluent in paints and adhesives, caffeine extractant, textile processing, solvent in production of color additives for food, cosmetics, drugs (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. Gavage
0,500,1000 MG/KG/50 PER GROUP
Papanicolaou Research Institute

Levels of Evidence

Male Rats: Inadequate Study
Type Organ/Tissue (Lesion)
Note
  • DESPITE THESE LIMITATIONS, TUBULAR CELL NEOPLASMS OF THE KIDNEY WERE OBSERVED IN RATS EXPOSED TO TRICHLOROETHYLENE AND INTERSTITIAL CELL NEOPLASMS OF THE TESTIS WERE OBSERVED IN MARSHALL RATS EXPOSED TO TRICHLOROETHYLENE.
Female Rats: Inadequate Study


Chemical (Study Title)
CASRN
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Trichloroethylene
79-01-6
08/19/1986 Degreaser, dry cleaning solvent, manufacture or organic chemicals and pharmaceuticals, heat exchange liquid, diluent in paints and adhesives, caffeine extractant, textile processing, solvent in production of color additives for food, cosmetics, drugs (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. Gavage
0,500,1000 MG/KG/50 PER GROUP
Papanicolaou Research Institute

Levels of Evidence

Male Rats: Inadequate Study
Type Organ/Tissue (Lesion)
Note
  • DESPITE THESE LIMITATIONS, TUBULAR CELL NEOPLASMS OF THE KIDNEY WERE OBSERVED IN RATS EXPOSED TO TRICHLOROETHYLENE AND INTERSTITIAL CELL NEOPLASMS OF THE TESTIS WERE OBSERVED IN MARSHALL RATS EXPOSED TO TRICHLOROETHYLENE.
Female Rats: Inadequate Study