National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8135

Target Organs and Levels of Evidence for TR-274

Toxicology and Carcinogenesis Studies of Tris(2-ethylhexyl)phosphate (CASRN 78-42-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
tris(2-Ethylhexyl)phosphate
78-42-2
10/28/1983Plasticizer for vinyl plastic and synthetic rubber, flame retardantGavage
MR: 0,2000,4000, FR: 0,1000,2000, M: 0,500,1000 MG/KG/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 2/50 9/50 12/50
Female Rats: No Evidence
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • THYROID GLAND: HYPERPLASIA, FOLLICULAR CELL
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 0/48 4/50 7/50
Non-Neoplastic Lesions
  • THYROID GLAND: HYPERPLASIA, FOLLICULAR CELL


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