National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8143

Target Organs and Levels of Evidence for TR-278

Toxicology and Carcinogenesis Studies of 2,6-Xylidine (2,6-Dimethylaniline) (CASRN 87-62-7) in Charles River CD Rats (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
2,6-Xylidine
87-62-7
09/22/1982Chemical intermediate for dyes and a metabolite of certain drugs, particularly the xylide group of local anesthetics. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
0,300,1000,3000 PPM/56 ANIMALS PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOMA 0/56 0/56 2/56 10/56; CARCINOMA 0/56 0/56 0/56 26/56
May Have Been Related
  • Subcutaneous Tissue: FIBROMA 0/56 1/56 2/56 4/56; FIBROSARCOMA 0/56 1/56 0/56 1/56
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOMA 0/56 0/56 1/56 6/56; CARCINOMA 0/56 0/56 1/56 24/56
May Have Been Related
  • Subcutaneous Tissue: FIBROMA 0/56 2/56 1/56 4/56; FIBROSARCOMA 1/56 0/56 1/56 3/56
  • Liver: NEOPLASTIC NODULE 0/56 1/56 2/56 4/56


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