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Target Organs and Levels of Evidence for TR-281

Toxicology and Carcinogenesis Studies of HC Red No. 3 [2,((Amino-2-nitrophenyl)amino)ethanol] (CASRN 2871-01-4) In F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
HC red 3
03/29/1985Dye in semi-permanent hair dyes. Gavage
R: 0,250,500, M: 0,125,250 MG/KG/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence
Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 11/50 6/50 16/50 OR CARCINOMA 17/50 9/50 21/50 COMBINED 25/50 15/50 35/50
Female Mice: Inadequate Study