National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8151

Target Organs and Levels of Evidence for TR-282

Toxicology and Carcinogenesis Studies of Chlorodibromomethane (CASRN 124-48-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Chlorodibromomethane
124-48-1
03/23/1984Organic synthesis. Lab chemical.Gavage
R: 0,40,80, M: 0,50,100 MG/KG/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence
Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 14/50 10/50 OR CARCINOMA 10/50 19/50 COMBINED 23/50 27/50
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 2/50 4/49 11/50 OR CARCINOMA 4/50 6/49 8/50 COMBINED 6/50 10/49 19/50


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