National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8153

Target Organs and Levels of Evidence for TR-284

Toxicology and Carcinogenesis Studies of Diallylphthalate (CASRN 131-17-9) in F344/N Rats (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Diallyl phthalate
131-17-9
03/23/1984Forms laminates with various fillers (e.g. Glass cloth). Electrical insulation. Dye carrier. Primary plasticizer.Gavage
0,50,100 MG/KG/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: FIBROSIS, PERIPORTAL; PIGMENTATION; HYPERPLASIA, BILE DUCT
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: LEUKEMIA 15/50 15/43 25/49
Non-Neoplastic Lesions
  • LIVER: FIBROSIS, PERIPORTAL; PIGMENTATION; HYPERPLASIA, BILE DUCT


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