National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8155

Target Organs and Levels of Evidence for TR-285

Toxicology and Carcinogenesis Studies of C.I. Basic Red 9 Monohydrochloride (Pararosaniline) (CASRN 569-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
C.I. Basic red 9 monohydrochloride
569-61-9
03/29/1985Dye for textiles, leather, photography and paper, and as biologic stainDosed-Feed
MR: 0, 1000, OR 2000 PPM -- FR AND M&F MICE 0, 500, OR 1000 PPM; 50/SEX/SPECIES
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Subcutaneous Tissue: FIBROMA 2/50 20/50 16/50
  • Skin: TRICHOEPITHELIOMA 0/50 0/50 7/50; SEBACEOUS ADENOMA 0/50 0/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 10/50
  • Thyroid Gland Follicular Cell: ADENOMA 0/49 0/46 9/44 OR CARCINOMA 0/49 5/46 18/44
  • Zymbal Gland: CARCINOMA 1/50 1/50 13/50
  • Liver: CARCINOMA 0/50 2/50 8/50
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Subcutaneous Tissue: FIBROMA 0/50 15/50 10/50
  • Thyroid Gland Follicular Cell: ADENOMA 0/47 0/48 4/50 OR CARCINOMA 0/47 2/48 2/50 COMBINED 0/47 2/48 6/50
  • Zymbal Gland: CARCINOMA 0/50 2/50 7/50
May Have Been Related
  • Mammary Gland: ADENOMA 0/50 3/50 1/50, FIBROADENOMA 22/50 31/50 29/50, OR ADENOCARCINOMA 2/50 2/50 5/50 COMBINED 23/50 32/50 32/50
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 10/50 20/50 27/50
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 3/49 19/50 37/49
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 1/48 7/47 7/45 OR MALIGNANT PHEOCHROMOCYTOMA 0/48 1/47 1/45 COMBINED 1/48 8/47 8/45
May Have Been Related
  • Hematopoietic System: LYMPHOMA 17/50 24/50 25/50


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