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Target Organs and Levels of Evidence for TR-287

Toxicology and Carcinogenesis Studies of Dimethyl Hydrogen Phosphite (CASRN 868-85-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Dimethyl hydrogen phosphite
868-85-9
07/27/1984Intermediate. Additive to lubricants. Adhesive. Fire retardant. Gavage
MR&M: 0,100,200, FR: 0,50,100 MG/KG/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 0/50 5/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/50 20/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 5/50
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 1/50 3/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 3/50
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/49 3/50
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 0/50 1/48; SQUAMOUS CELL CARCINOMA 0/50 0/50 1/48
Male Mice: No Evidence
Female Mice: No Evidence